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Все мутации со значимостью меньше 3 будут скрыты

ABCA1

rs#ГенотипОриентацияЗначимостьОписание
rs4149268AGminus2associated with higher HDL cholesterol

ABCB1

rs#ГенотипОриентацияЗначимостьОписание
rs1045642CCminus1increased risk of cannabis dependence, lower (normal) cancer risk
rs2032583TTminus
rs10248420AAplus1.1possibly less likely to remit on certain antidepressants
rs2235040GGminus1.1possibly lesser chances of remission only for inpatients on certain antidepressants
rs12720067GGminus

ABCC11

rs#ГенотипОриентацияЗначимостьОписание
rs17822931CCplus2Wet earwax. Normal body odour. Normal colostrum.

ABCC6

rs#ГенотипОриентацияЗначимостьОписание
rs2238472AGminus1most likely a benign polymorphism

ABCG2

rs#ГенотипОриентацияЗначимостьОписание
rs2231137AAminus1.5Slightly lower stroke risk

ABO

rs#ГенотипОриентацияЗначимостьОписание
rs8176746ACminusType B blood group (of ABO system); one allele

ACE

rs#ГенотипОриентацияЗначимостьОписание
rs4341CGplus2ACE I/D genotype
rs4343AGplus2ACE I/D genotype
rs4359CTplusslower responder

ACKR1

rs#ГенотипОриентацияЗначимостьОписание
rs2814778AAminus1Duffy-positive
rs12075GGplus1Duffy Fy(a+b-) phenotype likely (unless Duffy null mutation is present)

ACTN3

rs#ГенотипОриентацияЗначимостьОписание
rs1815739CCplus2.2Better performing muscles. Likely sprinter.

ACVR1B

rs#ГенотипОриентацияЗначимостьОписание
rs2854464AAplus2higher muscle strength

ADAMTS13

rs#ГенотипОриентацияЗначимостьОписание
rs28647808CGplus1.2among diabetic patients, somewhat higher risk for complications but also better response to therapy

ADCY2

rs#ГенотипОриентацияЗначимостьОписание
rs13166360GGplusHomozygous wild type at the ADCY2 gene

ADH1B

rs#ГенотипОриентацияЗначимостьОписание
rs1229984GGminus1.1normal oral/throat cancer risk; more frequent alcohol consumption

ADIPOQ

rs#ГенотипОриентацияЗначимостьОписание
rs17300539GGplus1increased risk of insulin resistance
rs266729CGplus1.80.73x decreased risk for colorectal cancer
rs1501299ACminus2slightly lower risk of breast cancer

ADRB1

rs#ГенотипОриентацияЗначимостьОписание
rs1801253CGplus

ADRB2

rs#ГенотипОриентацияЗначимостьОписание
rs1042713GGplusnormal
rs1042714GGpluscomplex; see details for increased risks

AGT

rs#ГенотипОриентацияЗначимостьОписание
rs699TTminusnormal risk of hypertension
rs3889728GGminusnormal risk

AKT1

rs#ГенотипОриентацияЗначимостьОписание
rs2494732CCplus2.1greater odds of cannabis-associated psychosis

ALDH2

rs#ГенотипОриентацияЗначимостьОписание
rs671GGplus2Alcohol Flush: Normal, doesn’t flush. Normal hangovers. Normal risk of Alcoholism. Normal risk of Esophageal Cancer. Disulfiram is effective for alcoholism.

ANK3

rs#ГенотипОриентацияЗначимостьОписание
rs10994336CTplus21.45x increased odds of developing bipolar disorder

ANKK1

rs#ГенотипОриентацияЗначимостьОписание
rs1800497CCminus3Normal (A2/A2)

ANXA11

rs#ГенотипОриентацияЗначимостьОписание
rs7091565TTplus1.26x risk of sarcoidosis
rs1049550CCminus1.6x increased risk of sarcoidosis

APOB

rs#ГенотипОриентацияЗначимостьОписание
rs693CTminuselevated lipids

APOC3

rs#ГенотипОриентацияЗначимостьОписание
rs2542052CCplus2better odds of living to 100

APOE

rs#ГенотипОриентацияЗначимостьОписание
rs7412CCplus1part of APOE4 genoset evaluation

ARID5B

rs#ГенотипОриентацияЗначимостьОписание
rs10821936TTplusnormal

ATG16L1

rs#ГенотипОриентацияЗначимостьОписание
rs10210302TTplus1.81.8x increased risk for Crohn’s disease
rs2241880CCminus2.52x-3x increased risk for Crohn’s disease in Caucasians

ATM

rs#ГенотипОриентацияЗначимостьОписание
rs664143CTminus2.5Higher risk for number of cancers
rs4585GTplus2average response to metformin in type 2 diabetics

ATP6V0A4

rs#ГенотипОриентацияЗначимостьОписание
rs3807153CTminus1carrier of a benign change

ATR

rs#ГенотипОриентацияЗначимостьОписание
rs2227928CTminuspoorer response to pancreatic cancer combined treatment

BARD1

rs#ГенотипОриентацияЗначимостьОписание
rs3768716AGminus1.7x higher risk of aggressive neuroblastoma
rs6435862GTplus1.51.7x higher risk of aggressive neuroblastoma

BCR

rs#ГенотипОриентацияЗначимостьОписание
rs140504AGplus1.4x increased risk for bipolar disorder

BDKRB2

rs#ГенотипОриентацияЗначимостьОписание
rs1799722TTplus1Associated with endurance performance

BRCA1

rs#ГенотипОриентацияЗначимостьОписание
rs1799966AGminus1.1very slightly increased breast cancer risk
rs16942AGminus2very slightly increased breast cancer risk

BTBD9

rs#ГенотипОриентацияЗначимостьОписание
rs9357271TTplus1Normal risk of developing restless legs syndrome
rs3923809AAplus21.9x risk for developing restless legs syndrome

C3

rs#ГенотипОриентацияЗначимостьОписание
rs11569562CCminusincreased risk for adult asthma
rs1047286CTminus1.31.3x increased risk for age-related macular degeneration
rs2230199CGminus21.6x+ risk of ARMD

C6orf10

rs#ГенотипОриентацияЗначимостьОписание
rs498422AAminusnormal risk for infertility in Chinese men

CD40

rs#ГенотипОриентацияЗначимостьОписание
rs4810485GTplus1.80.87 reduced risk for rheumatoid athritis

CD58

rs#ГенотипОриентацияЗначимостьОписание
rs12044852CCplus>1.24x risk

CDH13

rs#ГенотипОриентацияЗначимостьОписание
rs4783244GTplusAdiponectin levels significantly decreased x0.34 SD
rs8055236GGplus1.7common, but 2.2x higher risk for heart disease

CDKAL1

rs#ГенотипОриентацияЗначимостьОписание
rs7754840CGplus31.3x increased risk for type-2 diabetes
rs7756992AGplus1.3x increased risk for type-2 diabetes
rs9465871CTplus1.2x risk type-2 diabetes
rs6908425CCplus21.95x increased risk of developing Crohn’s disease

CDKN1B

rs#ГенотипОриентацияЗначимостьОписание
rs34330CTplus1.31.3x higher risk for endometrial cancer (in Chinese women)
rs34330TCplus

CDKN2B

rs#ГенотипОриентацияЗначимостьОписание
rs3217992GGminusnormal
rs1063192CCminus1.50.71x reduced risk of myocardial infarction

CETP

rs#ГенотипОриентацияЗначимостьОписание
rs183130CCpluslower HDL cholesterol
rs708272CTminus2.1Small reduction in heart disease risk from drinking alcohol
rs1864163GGplus2associated with higher HDL cholesterol
rs5882AGplus2Lower risk of dementia and Alzheimer’s disease. Higher good cholesterol.

CFH

rs#ГенотипОриентацияЗначимостьОписание
rs800292CCminus25% higher risk of Age related macular degeneration
rs1061147AAplus2.22.76x increased risk for Age Related Macular Degeneration.
rs380390CCminus2.1increased risk for ARMD
rs1329428GGminus2.12x increased risk for macular degeneration

CHI3L1

rs#ГенотипОриентацияЗначимостьОписание
rs4950928CCplus1.9Normal (higher) risk of Asthma.

CHRM2

rs#ГенотипОриентацияЗначимостьОписание
rs324640AGplus

CHRNA3

rs#ГенотипОриентацияЗначимостьОписание
rs1051730CTminus21.3x increased risk of lung cancer

CHRNA5

rs#ГенотипОриентацияЗначимостьОписание
rs16969968AGplus2.5slightly higher risk for nicotine dependence, lower risk for cocaine dependence

CHRNA7

rs#ГенотипОриентацияЗначимостьОписание
rs6494223CTplusin ALZ patients, increased risk of delusions

CHRNB3

rs#ГенотипОриентацияЗначимостьОписание
rs4950TTminus1Most common genotype in several populations; yet also higher leadership occupancy?

CLEC16A

rs#ГенотипОриентацияЗначимостьОписание
rs725613ACminus1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis risk
rs12708716AGplus1.2x risk of type-1 diabetes

CLOCK

rs#ГенотипОриентацияЗначимостьОписание
rs1801260CCminus2Lower ADHD symptom scores.

CLTCL1

rs#ГенотипОриентацияЗначимостьОписание
rs1061325CTplus2One copy of “hunter-gather” CLTCL1 gene variant + one “farmer” variant

CNR1

rs#ГенотипОриентацияЗначимостьОписание
rs1049353AGminus1less likely depressed in response to stress

CNTNAP2

rs#ГенотипОриентацияЗначимостьОписание
rs2538976AGminusNone

COL1A1

rs#ГенотипОриентацияЗначимостьОписание
rs1800012GTminusnormal

COL27A1

rs#ГенотипОриентацияЗначимостьОписание
rs7868992AGplus1.29x risk of Tourette’s Syndrome

COMT

rs#ГенотипОриентацияЗначимостьОписание
rs4633CTplus2higher risk for endometrial cancer
rs4680AGplusIntermediate dopamine levels, other effects
rs165599AGplus1

CTLA4

rs#ГенотипОриентацияЗначимостьОписание
rs4553808GGplus0.05x (decreased) risk for myasthenia gravis
rs231775AAplus1no increased risk of autoimmune thyroid disease
rs3087243GGplus1.5Increased risk for autoimmune diseases

CYP17A1

rs#ГенотипОриентацияЗначимостьОписание
rs2486758TTplus2Slightly lower prostate cancer risk; better response to AA/P treatment

CYP1A2

rs#ГенотипОриентацияЗначимостьОписание
rs2470890CCplusCYP1A2_1545T>C homozygote

CYP1B1

rs#ГенотипОриентацияЗначимостьОписание
rs1056836CCminusnormal

CYP2C8

rs#ГенотипОриентацияЗначимостьОписание
rs10509681TTplus1No increased risk of GI bleeding on NSAID drugs
rs11572080GGminus1No increased risk of GI bleeding on NSAID drugs

CYP2C9

rs#ГенотипОриентацияЗначимостьОписание
rs1799853CCplus1normal; no risk of altered warfarin metabolism or NSAID metabolism

CYP2D6

rs#ГенотипОриентацияЗначимостьОписание
rs1135840CGminus1.5Carrier of at least one CYP2D6 variant (non-CYP2D6*1)
rs5030865CCplus1normal

CYP2R1

rs#ГенотипОриентацияЗначимостьОписание
rs10741657GGplus1.25tend to have lower vitamin D levels
rs2060793GGplus1Higher serum levels of vitamin D

CYP3A5

rs#ГенотипОриентацияЗначимостьОписание
rs776746GGminus2.5CYP3A5*3 homozygote; CYP3A5 non-expressor

CYP4F2

rs#ГенотипОриентацияЗначимостьОписание
rs2108622CCplus2lower warfarin dosing

DBH

rs#ГенотипОриентацияЗначимостьОписание
rs1611115CCplusnormal
rs2007153AGminus1.5normal risk of schizophrenia in limited study

DGKH

rs#ГенотипОриентацияЗначимостьОписание
rs1012053ACplus20.625x reduced risk of Bipolar Disorder.
rs4142110CCplusnormal

DIO1

rs#ГенотипОриентацияЗначимостьОписание
rs11206244CCplus1no increased risk of thyroid hormone metabolism problems

DNM1

rs#ГенотипОриентацияЗначимостьОписание
rs3003609CTplus?

DPP6

rs#ГенотипОриентацияЗначимостьОписание
rs10260404CCplus21.60x risk of developing ALS

DRD2

rs#ГенотипОриентацияЗначимостьОписание
rs6277TTminus2normal schizophrenia risk, learns NoGo faster

DRD4

rs#ГенотипОриентацияЗначимостьОписание
rs11246226AAplus1increased risk of schizophrenia in limited study

DSP

rs#ГенотипОриентацияЗначимостьОписание
rs2076295GTplus1.2One copy of the risk allele (G), slightly increased risk for pulmonary fibrosis

EGF

rs#ГенотипОриентацияЗначимостьОписание
rs4444903AGplus23.5x risk of hep-cancer in cirrhosis patients; higher glioma risk

EGFR

rs#ГенотипОриентацияЗначимостьОписание
rs763317AGplusincreased lung cancer risk for never-smoking females
rs2293347GGminus1.1among NSCLC patients, better Gefitinib response; common

ELAC2

rs#ГенотипОриентацияЗначимостьОписание
rs5030739AGminus1.3Slight increase (1.3x) in risk for prostate cancer

ERAP1

rs#ГенотипОриентацияЗначимостьОписание
rs10050860CCplus1.3Normal risk (about 0.1%) for Ankylosing Spondylitis.
rs30187CCplus1.2Normal low risk (0.1%) for ankylosing spondylitis.

ERCC2

rs#ГенотипОриентацияЗначимостьОписание
rs13181TTplus1Normal risk for cutaneous melanoma

ESR1

rs#ГенотипОриентацияЗначимостьОписание
rs2881766TTplus1.5Slightly increased risk for pregnancy-induced hypertension
rs9340799AAplus2Women have lower risk of Endometriosis but normal risk for Endometrial Cancer, and more cognitive impairment with age.
rs3020314CCplus0.42x reduced lymphoma risk
rs2179922AGplus

F12

rs#ГенотипОриентацияЗначимостьОписание
rs1801020CTminus1.51.31x increased risk of heart disease

FAAH

rs#ГенотипОриентацияЗначимостьОписание
rs324420ACplusnormal

FABP2

rs#ГенотипОриентацияЗначимостьОписание
rs1799883GGminusThis genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates.

FADS1

rs#ГенотипОриентацияЗначимостьОписание
rs174548CGplusintermediate phosphatidylcholine values

FADS2

rs#ГенотипОриентацияЗначимостьОписание
rs1535AGplus4+ IQ points for breastfeeding
rs174575CGplus

FAM71F1

rs#ГенотипОриентацияЗначимостьОписание
rs6971091AAplus>2x increased risk for familial obesity

FCGR2A

rs#ГенотипОриентацияЗначимостьОписание
rs1801274CTminus1.5complex; generally greater risk for cancer progression

FGFR2

rs#ГенотипОриентацияЗначимостьОписание
rs3750817CTplus20.78x reduced risk for breast cancer
rs2981579CTminus1.20x risk for breast cancer
rs2981578AGminus1.20x increased breast cancer risk
rs1219648AGplus21.20x risk for breast cancer
rs2420946CTplus21.20x risk for breast cancer
rs2981582CTminus31.3x higher risk of ER+ breast cancer

FGFR4

rs#ГенотипОриентацияЗначимостьОписание
rs351855CTminus21.2x increased risk for prostate cancer

FKBP5

rs#ГенотипОриентацияЗначимостьОписание
rs7757037AGplus0.68x decreased risk for bipolar disorder
rs1360780CTplus21.3x increased risk for depression

FTO

rs#ГенотипОриентацияЗначимостьОписание
rs1558902TTplusNormal
rs3751812GGplusnormal
rs9939609TTplus1.5lower risk of obesity and Type-2 diabetes
rs16953002GGplus1Slightly lower risk of melanoma in individuals with low BMI

FUT1

rs#ГенотипОриентацияЗначимостьОписание
rs838133CTminus1.2Sweeth tooth tendency; slightly higher odds of preferring candy

FUT2

rs#ГенотипОриентацияЗначимостьОписание
rs492602CTminus1Normal B12 levels

GABRA2

rs#ГенотипОриентацияЗначимостьОписание
rs279858AGminusNone

GADL1

rs#ГенотипОриентацияЗначимостьОписание
rs17026688CCplus1common

GATA3

rs#ГенотипОриентацияЗначимостьОписание
rs4143094TTplus3.1higher (by 39%) risk for colorectal cancer correlated with consumption of processed meats

GBA

rs#ГенотипОриентацияЗначимостьОписание
rs104886460TTminus7Gaucher disease

GCK

rs#ГенотипОриентацияЗначимостьОписание
rs1799884AGminus21.3x increased risk for Type 2 Diabetes. Mothers have babies 27g heavier.

GDF5

rs#ГенотипОриентацияЗначимостьОписание
rs143383CTminus1.21.1x increased risk for osteoarthritis

GLCCI1

rs#ГенотипОриентацияЗначимостьОписание
rs37973AAplus2possibly better response to inhaled corticosteroids in asthma

GNB3

rs#ГенотипОриентацияЗначимостьОписание
rs5443CCplus1.5normal, but higher risk for several conditions

GPX4

rs#ГенотипОриентацияЗначимостьОписание
rs713041TTplus>1.3x increased risk of death if diagnosed with breast cancer

GRIK4

rs#ГенотипОриентацияЗначимостьОписание
rs1954787CCplus~10% more likely to respond to citalopram

GSK3B

rs#ГенотипОриентацияЗначимостьОписание
rs334558GGpluscommon

GSTP1

rs#ГенотипОриентацияЗначимостьОписание
rs1695AGplus?

GYPB

rs#ГенотипОриентацияЗначимостьОписание
rs7683365AGplus1MNS blood group S/s status predicted

HCRTR2

rs#ГенотипОриентацияЗначимостьОписание
rs2653349GGplus1.12-6x increased risk for cluster headaches

HERC2

rs#ГенотипОриентацияЗначимостьОписание
rs12913832GGplus2.5blue eye color, 99% of the time
rs1667394AAminus1.5blond hair & blue eyes is 4x more likely

HMGA2

rs#ГенотипОриентацияЗначимостьОписание
rs10784502CTplus1Slightly higher intracranial volume
rs1042725CTplus1.5~0.4cm taller

HMGCR

rs#ГенотипОриентацияЗначимостьОписание
rs17238540GTplusnot as responsive to statin treatment

HNF1B

rs#ГенотипОриентацияЗначимостьОписание
rs4430796AAplus2.11.38x increased risk for prostate cancer

HSD17B4

rs#ГенотипОриентацияЗначимостьОписание
rs25640AGplus1benign polymorphism

HTR2A

rs#ГенотипОриентацияЗначимостьОписание
rs6313CCminushigher risk for RA
rs6311CCplus33.6x increased risk of sexual dysfunction when taking SSRI Antidepressants.

IFNL4

rs#ГенотипОриентацияЗначимостьОписание
rs12979860CCplus2~80% of such hepatitis C patients respond to treatment

IGF2BP2

rs#ГенотипОриентацияЗначимостьОписание
rs4402960GTplus21.2x increased risk for type-2 diabetes, ~1x risk for gestational diabetes
rs1470579ACplus1.2x increased risk for type-2 diabetes

IKZF1

rs#ГенотипОриентацияЗначимостьОписание
rs4132601GTplus1.7somewhat (1.7x) increased risk for acute lymphoblastic leukemia

IKZF3

rs#ГенотипОриентацияЗначимостьОписание
rs9303277CCplus1Normal risk of developing primary biliary cirrhosis

IL10

rs#ГенотипОриентацияЗначимостьОписание
rs1800871CTminus0.5x decreased risk for endometriosis
rs1800896AAminus21.8x increased prostate cancer risk

IL12B

rs#ГенотипОриентацияЗначимостьОписание
rs3212227AAminus1.51.43x increased risk of developing psoriasis and psoriatic arthritis
rs3213094GGminus

IL17A

rs#ГенотипОриентацияЗначимостьОписание
rs2275913AAplus3x increased gastric cancer risk. Increased risk of Acute Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation

IL18

rs#ГенотипОриентацияЗначимостьОписание
rs187238GGminus2.5hypertension increases risk 3.75x for sudden cardiac death

IL1B

rs#ГенотипОриентацияЗначимостьОписание
rs16944GGplus2Slightly increased (~2x or less) risk for certain mental disorders

IL23R

rs#ГенотипОриентацияЗначимостьОписание
rs1004819CTminus11.5x risk of Crohn’s disease, 1.2 for developing ankylosing spondylitis
rs2201841CTminus21.5x increased risk for Crohn’s disease; 2x increased risk for Graves’ disease
rs11209026GGplus1.1Normal, but higher risk for certain autoimmune diseases.
rs10889677ACplus21.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves disease
rs1495965GGminusnormal risk

IL2RA

rs#ГенотипОриентацияЗначимостьОписание
rs12722489GGminusa slight increase in risk of developing multiple sclerosis

IL2RB

rs#ГенотипОриентацияЗначимостьОписание
rs743777AAplus

IL4

rs#ГенотипОриентацияЗначимостьОписание
rs2243250TTplus20.33x decreased risk for myocardial infarction if younger than 50

IL6

rs#ГенотипОриентацияЗначимостьОписание
rs1800795CGpluscomplex; see details

IVD

rs#ГенотипОриентацияЗначимостьОписание
rs2034650CTminus0.13x risk of pulmonary fibrosis in Koreans

KCNQ1

rs#ГенотипОриентацияЗначимостьОписание
rs11601907CTplus1variant allele is designated benign in ClinVar

KIF1B

rs#ГенотипОриентацияЗначимостьОписание
rs10492972CCplusconflicting reports; possible slight increased risk for multiple sclerosis

KITLG

rs#ГенотипОриентацияЗначимостьОписание
rs995030GGplus1.5non-protective against testicular cancer
rs4474514AAplus1.8>3x increased testicular cancer risk for men

LIPC

rs#ГенотипОриентацияЗначимостьОписание
rs1800588CCplus1.6normal HDL-C levels

LOC105377329

rs#ГенотипОриентацияЗначимостьОписание
rs356220CCplus

LOC729065

rs#ГенотипОриентацияЗначимостьОписание
rs2200733CTplus31.4x increased risk of Atrial Fibrillation and ischemic stroke.

LOXL1

rs#ГенотипОриентацияЗначимостьОписание
rs3825942AGplus1.8possibly lower glaucoma risk
rs2165241CTplus2.24.4x increased risk of exfoliation glaucoma

LPL

rs#ГенотипОриентацияЗначимостьОписание
rs326GGplusnormal risk

LPP

rs#ГенотипОриентацияЗначимостьОписание
rs9851967TTplus0.88x risk of vitiligo in Chinese

LRP1

rs#ГенотипОриентацияЗначимостьОписание
rs11172113CCplus1.20.8x lower risk for migraines

LRP5

rs#ГенотипОриентацияЗначимостьОписание
rs4988300GTplus
rs3736228CTplus1.3increased risk for osteoporosis

LTA

rs#ГенотипОриентацияЗначимостьОписание
rs1041981CCplusnormal

MAP2K5

rs#ГенотипОриентацияЗначимостьОписание
rs12593813AGplus1.50.71x risk for restless legs
rs4489954GTplus1.50.69x risk risk of developing restless legs syndrome
rs2241423GGplus1Normal risk for obesity

MAPT

rs#ГенотипОриентацияЗначимостьОписание
rs1800547AAplus1MAPT H1/H1 diplotype

MC4R

rs#ГенотипОриентацияЗначимостьОписание
rs2229616GGminus2lower BMI; decreased obesity risk

MCM6

rs#ГенотипОриентацияЗначимостьОписание
rs4988235CCminus2.5likely to be lactose intolerant as an adult
rs182549CCplus2possibly lactose intolerant

MEIS1

rs#ГенотипОриентацияЗначимостьОписание
rs12469063AAplus1Normal risk of developing restless legs syndrome
rs2300478TTplus1Normal risk of developing restless legs syndrome

MMEL1

rs#ГенотипОриентацияЗначимостьОписание
rs3890745AGminus

MMP9

rs#ГенотипОриентацияЗначимостьОписание
rs3918242TTplus1.33x increased risk for MI; also check haplotype

MTHFD1

rs#ГенотипОриентацияЗначимостьОписание
rs2236225CTminus1.25Possible increased risk of birth defects

MTHFS

rs#ГенотипОриентацияЗначимостьОписание
rs6495446TTplus20.64x reduced risk for chronic kidney disease

MTNR1B

rs#ГенотипОриентацияЗначимостьОписание
rs10830963GGplus3.1increased type-2 diabetes risk; higher gestational diabetes risk

MTRR

rs#ГенотипОриентацияЗначимостьОписание
rs1801394GGplus21.4x higher risk for meningiomas

MTTP

rs#ГенотипОриентацияЗначимостьОписание
rs3816873CTplusNone

NADSYN1

rs#ГенотипОриентацияЗначимостьОписание
rs12785878GTplus1.5slightly increased (1.2x) risk for vitamin D insufficiency

NAT1

rs#ГенотипОриентацияЗначимостьОписание
rs1057126TTplus
rs15561CCplus

NAT2

rs#ГенотипОриентацияЗначимостьОписание
rs1799930AGplus1.7Possibly slightly increased risk of hearing loss

NBPF3

rs#ГенотипОриентацияЗначимостьОписание
rs4654748CTplus21.45 ng/mL lower Vitamin B6 blood concentration

NCAN

rs#ГенотипОриентацияЗначимостьОписание
rs1064395GGplusNormal risk of bipolar disorder or schizophrenia

NF1

rs#ГенотипОриентацияЗначимостьОписание
rs137854557GGplus1Miscall in Ancestry v2c data (most likely)

NGF

rs#ГенотипОриентацияЗначимостьОписание
rs6330CTminusnormal

NOS1AP

rs#ГенотипОриентацияЗначимостьОписание
rs10918594CGplusaverage QT interval

NOS2

rs#ГенотипОриентацияЗначимостьОписание
rs4795067AGplus1.2slight increase in risk for psoriatic arthritis

NOS3

rs#ГенотипОриентацияЗначимостьОписание
rs891512AAplus3Higher blood pressure than G;G

NPPA

rs#ГенотипОриентацияЗначимостьОписание
rs5065AGplusnormal risk

NQO1

rs#ГенотипОриентацияЗначимостьОписание
rs1800566CTminus1.8Possible Lower Lung Cancer risk

NRG1

rs#ГенотипОриентацияЗначимостьОписание
rs6994992CTplus1

NSD1

rs#ГенотипОриентацияЗначимостьОписание
rs28932178CTplus

OCA2

rs#ГенотипОриентацияЗначимостьОписание
rs4778138AAplus1freckles more likely

OPRM1

rs#ГенотипОриентацияЗначимостьОписание
rs2281617CCplus2Normal (better) response to amphetamine

OXTR

rs#ГенотипОриентацияЗначимостьОписание
rs53576AAplus2.8Lack of empathy?

P2RY11

rs#ГенотипОриентацияЗначимостьОписание
rs2305795AGplus21.28x higher risk of narcolepsy compared to (G;G) genotype

PADI4

rs#ГенотипОриентацияЗначимостьОписание
rs2240340AGminus1.5slightly increased (1.5x) risk for RA

PADI6

rs#ГенотипОриентацияЗначимостьОписание
rs7538876AGplus1.8Normal risk of Basal Cell Carcinoma.

PALB2

rs#ГенотипОриентацияЗначимостьОписание
rs420259TTminus1.5Normal risk of Bipolar Disorder.

PCSK9

rs#ГенотипОриентацияЗначимостьОписание
rs11591147GTplus3.52-3 fold lower risk of heart disease

PDE4B

rs#ГенотипОриентацияЗначимостьОписание
rs4655595AAplusnormal
rs1321172CCminuscommon

PDE4D

rs#ГенотипОриентацияЗначимостьОписание
rs966221CCminus1.51.5x increased stroke risk certain populations

PKD1L3

rs#ГенотипОриентацияЗначимостьОписание
rs9938025AAplus2Lower odds of dry earwax in Europeans.

PLCE1

rs#ГенотипОриентацияЗначимостьОписание
rs2274223AGplus21.5x increased risk for stomach & esophageal cancer (seen in Han Chinese)

PLD3

rs#ГенотипОриентацияЗначимостьОписание
rs145999145GGplus1common

PNPLA3

rs#ГенотипОриентацияЗначимостьОписание
rs738409GGminus2.1most common genotype; slightly less damage from alcohol

PON1

rs#ГенотипОриентацияЗначимостьОписание
rs662AAminus2~2x higher risk of of coronary heart disease reported in some studies, but lower risk seen in other studies
rs854560AAplus2higher risk for heart disease, diabetic retinopathy

POR

rs#ГенотипОриентацияЗначимостьОписание
rs1057868CTplusnormal

PPARGC1A

rs#ГенотипОриентацияЗначимостьОписание
rs2290602GTplus22.7x increased risk for nonalcoholic fatty liver disease

PRNP

rs#ГенотипОриентацияЗначимостьОписание
rs1799990AGplus2.1Resistance to vCJD (PrP 129 Met/Val heterozygote), 4.6x reduced risk of sporadic CJD and 0.87x reduced risk for late-onset Alzheimer in a Caucasian population

PRRC2A

rs#ГенотипОриентацияЗначимостьОписание
rs1046089AAplusnormal

PTGS2

rs#ГенотипОриентацияЗначимостьОписание
rs5275CTminus0.68x decreased risk for bladder cancer

PTPRD

rs#ГенотипОриентацияЗначимостьОписание
rs1975197CCminus1Normal risk of developing restless legs syndrome
rs4626664GGplus1Normal risk of developing restless legs syndrome

RELN

rs#ГенотипОриентацияЗначимостьОписание
rs3914132TTplus1Normal (not lower) otosclerosis risk

RGS2

rs#ГенотипОриентацияЗначимостьОписание
rs4606GGpluscomplex; possible association with anxiety related behaviours

RNASEL

rs#ГенотипОриентацияЗначимостьОписание
rs3738579CTminus1.10.5x decreased risk for cervical cancer, HNSCC, and breast cancer (reported in 2008)

RTEL1

rs#ГенотипОриентацияЗначимостьОписание
rs6010620GGplus1.41.4x higher risk for glioma development; but this is the common allele. 1.4x higher risk for atopic dermatitis in Han Chinese

SCARB1

rs#ГенотипОриентацияЗначимостьОписание
rs5888CTminus2.53x higher risk for age-related macular degeneration
rs4765623CTplusmore likely to gain weight if taking olanzapine

SELE

rs#ГенотипОриентацияЗначимостьОписание
rs5361ACminusnormal risk

SERPINF1

rs#ГенотипОриентацияЗначимостьОписание
rs1136287TTplus23.9x increased risk of wet ARMD in a Taiwanese Chinese population

SHROOM3

rs#ГенотипОриентацияЗначимостьОписание
rs17319721AGplus1.5reported to have some negative associations with kidney function

SLC14A1

rs#ГенотипОриентацияЗначимостьОписание
rs1058396GGplus1Jk(a+/b-) Kidd blood group, barring other variants

SLC19A1

rs#ГенотипОриентацияЗначимостьОписание
rs12483377AGplus1benign polymorphism

SLC2A9

rs#ГенотипОриентацияЗначимостьОписание
rs6855911AAplus2normal, but increased risk of gout
rs12498742AAplus1.51.25 increased risk for gout
rs7442295AAplus2~4x higher risk for hyperuracemia
rs3775948CGminus1.6slightly higher risk for gout

SLC30A8

rs#ГенотипОриентацияЗначимостьОписание
rs13266634CCplus3increased risk for type-2 diabetes
rs3802177CCminus1.16x increased risk for type-2 diabetes

SLC45A2

rs#ГенотипОриентацияЗначимостьОписание
rs16891982CCplus1.1generally non-European, but if European, 7x more likely to have black hair

SLC4A1

rs#ГенотипОриентацияЗначимостьОписание
rs2285644CCminus1Diego blood group Di(a-b+); found in > 99% of Caucasians and Blacks
rs5036AGminus2Memphis variant of erythrocyte Band 3 glycoprotein

SLC6A2

rs#ГенотипОриентацияЗначимостьОписание
rs3785143CTplus1may be associated with ADHD

SLC6A3

rs#ГенотипОриентацияЗначимостьОписание
rs27072CCplus22x risk of severe alcohol withdrawal. Possible increased odds of ADHD.
rs460000CCminus2Better response to amphetamine

SLC6A4

rs#ГенотипОриентацияЗначимостьОписание
rs1042173GTminusnormal
rs25532CCminusmay be part of a haplotype associated with OCD

SLCO1B3

rs#ГенотипОриентацияЗначимостьОписание
rs11045585AAplus224% chance (lower than average) of docetaxel-induced leukopenia/neutropenia

SMAD7

rs#ГенотипОриентацияЗначимостьОписание
rs4939827CCplus10.73x decreased risk for colorectal cancer
rs12953717CCplus1.37x increased risk for colorectal cancer
rs4464148TTplus1Normal risk for colorectal cancer

SMOC2

rs#ГенотипОриентацияЗначимостьОписание
rs13208776GGplushigher risk for generalized vitiligo

SNAP25

rs#ГенотипОриентацияЗначимостьОписание
rs363050AGplus1.1
rs3746544AAminusAssociated with ADHD

SNCA

rs#ГенотипОриентацияЗначимостьОписание
rs356168AAplus2slight decrease in risk for Parkinson’s disease
rs2736990TTminus1Normal risk of developing Parkinson’s Disease

SOD2

rs#ГенотипОриентацияЗначимостьОписание
rs4880CTminus1.1complex! see rs4880

SOD3

rs#ГенотипОриентацияЗначимостьОписание
rs699473TTplus1Normal brain tumor risk

SPIB

rs#ГенотипОриентацияЗначимостьОписание
rs3745516AGplus1.5Slightly increased risk of developing primary biliary cirrhosis

SPINK5

rs#ГенотипОриентацияЗначимостьОписание
rs2303067AAplus1.8x risk

SREBF1

rs#ГенотипОриентацияЗначимостьОписание
rs11868035AAplus1.19x increased risk for T2D

STAT4

rs#ГенотипОриентацияЗначимостьОписание
rs10168266CCplusnormal risk of Sjogren’s syndrome
rs7574865GGplus1normal risk of rheumatoid arthritis, SLE, Sjögren’s syndrome, type-1 diabetes, and primary biliary cirrhosis.
rs7582694GGplusnormal

SULT2A1

rs#ГенотипОриентацияЗначимостьОписание
rs2547231TTminus2Increased blood metabolite levels

TAS2R38

rs#ГенотипОриентацияЗначимостьОписание
rs713598GGminus1.1Possibly unable to taste bitter in some foods.

TBX21

rs#ГенотипОриентацияЗначимостьОписание
rs4794067TTplus1.1Lower risk of Aspirin Induced Asthma. Normal (higher) risk of lupus and intractable Grave’s Disease.
rs17250932TTplus1.1Normal. Not protective against lupus and intractable Graves’ disease.

TCF7L2

rs#ГенотипОриентацияЗначимостьОписание
rs3814570CCplus1Normal risk of developing Crohn’s disease
rs7903146TTplus3.52x increased risk for Type-2 diabetes
rs12255372TTplus2.2slight increases (~1.5x) in risk for type-2 diabetes and possibly breast cancer and aggressive prostate cancer

TERT

rs#ГенотипОриентацияЗначимостьОписание
rs2736100GTminus1.31.3x higher risk for glioma development, 2.1x risk of pulmonary fibrosis

TF

rs#ГенотипОриентацияЗначимостьОписание
rs1049296CTplus1.1Heterozygote carrying both C1 and C2 transferrin subtypes; very slightly higher risk for Alzheimers

TGFB1

rs#ГенотипОриентацияЗначимостьОписание
rs1800469CCminus1lower TGF-β1 levels, higher risk for COPD?

TLR2

rs#ГенотипОриентацияЗначимостьОписание
rs4696480ATplus1preterm birth

TLR3

rs#ГенотипОриентацияЗначимостьОписание
rs3775291AGminus2.10.71x decreased risk for dry age related macular degeneration

TLR4

rs#ГенотипОриентацияЗначимостьОписание
rs1554973CTplusincreased risk for chorionic plate inflammation

TMPRSS6

rs#ГенотипОриентацияЗначимостьОписание
rs855791CCminusnormal

TNFSF15

rs#ГенотипОриентацияЗначимостьОписание
rs4979462CCplus1Normal risk of developing primary biliary cirrhosis

TOMM40

rs#ГенотипОриентацияЗначимостьОписание
rs2075650AGplus2possibly 2x higher Alzheimer’s risk

TP53

rs#ГенотипОриентацияЗначимостьОписание
rs1042522GGminus2Common variant. Slightly shorter lifespan.

TPH2

rs#ГенотипОриентацияЗначимостьОписание
rs4570625GTplusnormal
rs4565946CCplusRisk of early-onset OCD
rs1843809TTplus1Most common genotype worldwide

TRA

rs#ГенотипОриентацияЗначимостьОписание
rs1154155GTplus1.51.94x increased risk for narcolepsy

TRAF1

rs#ГенотипОриентацияЗначимостьОписание
rs3761847AGplus2.11.32 x risk of rheumatoid arthritis.

TRPM8

rs#ГенотипОриентацияЗначимостьОписание
rs10166942CTplus1.10.85x lower risk for migraines

TYR

rs#ГенотипОриентацияЗначимостьОписание
rs1042602AAplusassociated with the absence of freckles

VDR

rs#ГенотипОриентацияЗначимостьОписание
rs731236CTminus
rs1544410AGminusIntermediate risk of low bone mineral density disorders
rs4516035TTplusnormal

VEGFA

rs#ГенотипОриентацияЗначимостьОписание
rs699947AAplus1.36x increased risk for thyroid cancer in men

VKORC1

rs#ГенотипОриентацияЗначимостьОписание
rs8050894CGplusaverage warfarin response (~5 mg/day)
rs9923231CTplus2reduced warfarin dose if treated for VTE

WWC1

rs#ГенотипОриентацияЗначимостьОписание
rs17070145CTplus2increased memory performance

XPC

rs#ГенотипОриентацияЗначимостьОписание
rs2228001ACminusnormal

XRCC1

rs#ГенотипОриентацияЗначимостьОписание
rs25487GGminus22x higher risk for skin cancer; possibly other cancers

ZNF365

rs#ГенотипОриентацияЗначимостьОписание
rs7089814TTplus2smaller breast size (normal in European female)
rs2393903GGminus1.37x increased risk for atopic dermatitis
rs7076156AAplus2