ABCA1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4149268 | AG | minus | 2 | associated with higher HDL cholesterol |
ABCB1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1045642 | CC | minus | 1 | increased risk of cannabis dependence, lower (normal) cancer risk |
| rs2032583 | TT | minus | ||
| rs10248420 | AA | plus | 1.1 | possibly less likely to remit on certain antidepressants |
| rs2235040 | GG | minus | 1.1 | possibly lesser chances of remission only for inpatients on certain antidepressants |
| rs12720067 | GG | minus |
ABCC11
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs17822931 | CC | plus | 2 | Wet earwax. Normal body odour. Normal colostrum. |
ABCC6
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2238472 | AG | minus | 1 | most likely a benign polymorphism |
ABCG2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2231137 | AA | minus | 1.5 | Slightly lower stroke risk |
ABO
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs8176746 | AC | minus | Type B blood group (of ABO system); one allele |
ACE
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4341 | CG | plus | 2 | ACE I/D genotype |
| rs4343 | AG | plus | 2 | ACE I/D genotype |
| rs4359 | CT | plus | slower responder |
ACKR1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2814778 | AA | minus | 1 | Duffy-positive |
| rs12075 | GG | plus | 1 | Duffy Fy(a+b-) phenotype likely (unless Duffy null mutation is present) |
ACTN3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1815739 | CC | plus | 2.2 | Better performing muscles. Likely sprinter. |
ACVR1B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2854464 | AA | plus | 2 | higher muscle strength |
ADAMTS13
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs28647808 | CG | plus | 1.2 | among diabetic patients, somewhat higher risk for complications but also better response to therapy |
ADCY2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs13166360 | GG | plus | Homozygous wild type at the ADCY2 gene |
ADH1B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1229984 | GG | minus | 1.1 | normal oral/throat cancer risk; more frequent alcohol consumption |
ADIPOQ
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs17300539 | GG | plus | 1 | increased risk of insulin resistance |
| rs266729 | CG | plus | 1.8 | 0.73x decreased risk for colorectal cancer |
| rs1501299 | AC | minus | 2 | slightly lower risk of breast cancer |
ADRB1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1801253 | CG | plus |
ADRB2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1042713 | GG | plus | normal | |
| rs1042714 | GG | plus | complex; see details for increased risks |
AGT
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs699 | TT | minus | normal risk of hypertension | |
| rs3889728 | GG | minus | normal risk |
AKT1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2494732 | CC | plus | 2.1 | greater odds of cannabis-associated psychosis |
ALDH2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs671 | GG | plus | 2 | Alcohol Flush: Normal, doesn’t flush. Normal hangovers. Normal risk of Alcoholism. Normal risk of Esophageal Cancer. Disulfiram is effective for alcoholism. |
ANK3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10994336 | CT | plus | 2 | 1.45x increased odds of developing bipolar disorder |
ANKK1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1800497 | CC | minus | 3 | Normal (A2/A2) |
ANXA11
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs7091565 | TT | plus | 1.26x risk of sarcoidosis | |
| rs1049550 | CC | minus | 1.6x increased risk of sarcoidosis |
APOB
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs693 | CT | minus | elevated lipids |
APOC3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2542052 | CC | plus | 2 | better odds of living to 100 |
APOE
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs7412 | CC | plus | 1 | part of APOE4 genoset evaluation |
ARID5B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10821936 | TT | plus | normal |
ATG16L1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10210302 | TT | plus | 1.8 | 1.8x increased risk for Crohn’s disease |
| rs2241880 | CC | minus | 2.5 | 2x-3x increased risk for Crohn’s disease in Caucasians |
ATM
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs664143 | CT | minus | 2.5 | Higher risk for number of cancers |
| rs4585 | GT | plus | 2 | average response to metformin in type 2 diabetics |
ATP6V0A4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3807153 | CT | minus | 1 | carrier of a benign change |
ATR
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2227928 | CT | minus | poorer response to pancreatic cancer combined treatment |
BARD1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3768716 | AG | minus | 1.7x higher risk of aggressive neuroblastoma | |
| rs6435862 | GT | plus | 1.5 | 1.7x higher risk of aggressive neuroblastoma |
BCR
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs140504 | AG | plus | 1.4x increased risk for bipolar disorder |
BDKRB2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1799722 | TT | plus | 1 | Associated with endurance performance |
BRCA1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1799966 | AG | minus | 1.1 | very slightly increased breast cancer risk |
| rs16942 | AG | minus | 2 | very slightly increased breast cancer risk |
BTBD9
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs9357271 | TT | plus | 1 | Normal risk of developing restless legs syndrome |
| rs3923809 | AA | plus | 2 | 1.9x risk for developing restless legs syndrome |
C3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs11569562 | CC | minus | increased risk for adult asthma | |
| rs1047286 | CT | minus | 1.3 | 1.3x increased risk for age-related macular degeneration |
| rs2230199 | CG | minus | 2 | 1.6x+ risk of ARMD |
C6orf10
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs498422 | AA | minus | normal risk for infertility in Chinese men |
CD40
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4810485 | GT | plus | 1.8 | 0.87 reduced risk for rheumatoid athritis |
CD58
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs12044852 | CC | plus | >1.24x risk |
CDH13
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4783244 | GT | plus | Adiponectin levels significantly decreased x0.34 SD | |
| rs8055236 | GG | plus | 1.7 | common, but 2.2x higher risk for heart disease |
CDKAL1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs7754840 | CG | plus | 3 | 1.3x increased risk for type-2 diabetes |
| rs7756992 | AG | plus | 1.3x increased risk for type-2 diabetes | |
| rs9465871 | CT | plus | 1.2x risk type-2 diabetes | |
| rs6908425 | CC | plus | 2 | 1.95x increased risk of developing Crohn’s disease |
CDKN1B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs34330 | CT | plus | 1.3 | 1.3x higher risk for endometrial cancer (in Chinese women) |
| rs34330 | TC | plus |
CDKN2B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3217992 | GG | minus | normal | |
| rs1063192 | CC | minus | 1.5 | 0.71x reduced risk of myocardial infarction |
CETP
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs183130 | CC | plus | lower HDL cholesterol | |
| rs708272 | CT | minus | 2.1 | Small reduction in heart disease risk from drinking alcohol |
| rs1864163 | GG | plus | 2 | associated with higher HDL cholesterol |
| rs5882 | AG | plus | 2 | Lower risk of dementia and Alzheimer’s disease. Higher good cholesterol. |
CFH
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs800292 | CC | minus | 2 | 5% higher risk of Age related macular degeneration |
| rs1061147 | AA | plus | 2.2 | 2.76x increased risk for Age Related Macular Degeneration. |
| rs380390 | CC | minus | 2.1 | increased risk for ARMD |
| rs1329428 | GG | minus | 2.1 | 2x increased risk for macular degeneration |
CHI3L1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4950928 | CC | plus | 1.9 | Normal (higher) risk of Asthma. |
CHRM2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs324640 | AG | plus |
CHRNA3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1051730 | CT | minus | 2 | 1.3x increased risk of lung cancer |
CHRNA5
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs16969968 | AG | plus | 2.5 | slightly higher risk for nicotine dependence, lower risk for cocaine dependence |
CHRNA7
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs6494223 | CT | plus | in ALZ patients, increased risk of delusions |
CHRNB3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4950 | TT | minus | 1 | Most common genotype in several populations; yet also higher leadership occupancy? |
CLEC16A
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs725613 | AC | minus | 1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis risk | |
| rs12708716 | AG | plus | 1.2x risk of type-1 diabetes |
CLOCK
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1801260 | CC | minus | 2 | Lower ADHD symptom scores. |
CLTCL1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1061325 | CT | plus | 2 | One copy of “hunter-gather” CLTCL1 gene variant + one “farmer” variant |
CNR1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1049353 | AG | minus | 1 | less likely depressed in response to stress |
CNTNAP2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2538976 | AG | minus | None |
COL1A1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1800012 | GT | minus | normal |
COL27A1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs7868992 | AG | plus | 1.29x risk of Tourette’s Syndrome |
COMT
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4633 | CT | plus | 2 | higher risk for endometrial cancer |
| rs4680 | AG | plus | Intermediate dopamine levels, other effects | |
| rs165599 | AG | plus | 1 |
CTLA4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4553808 | GG | plus | 0.05x (decreased) risk for myasthenia gravis | |
| rs231775 | AA | plus | 1 | no increased risk of autoimmune thyroid disease |
| rs3087243 | GG | plus | 1.5 | Increased risk for autoimmune diseases |
CYP17A1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2486758 | TT | plus | 2 | Slightly lower prostate cancer risk; better response to AA/P treatment |
CYP1A2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2470890 | CC | plus | CYP1A2_1545T>C homozygote |
CYP1B1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1056836 | CC | minus | normal |
CYP2C8
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10509681 | TT | plus | 1 | No increased risk of GI bleeding on NSAID drugs |
| rs11572080 | GG | minus | 1 | No increased risk of GI bleeding on NSAID drugs |
CYP2C9
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1799853 | CC | plus | 1 | normal; no risk of altered warfarin metabolism or NSAID metabolism |
CYP2D6
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1135840 | CG | minus | 1.5 | Carrier of at least one CYP2D6 variant (non-CYP2D6*1) |
| rs5030865 | CC | plus | 1 | normal |
CYP2R1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10741657 | GG | plus | 1.25 | tend to have lower vitamin D levels |
| rs2060793 | GG | plus | 1 | Higher serum levels of vitamin D |
CYP3A5
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs776746 | GG | minus | 2.5 | CYP3A5*3 homozygote; CYP3A5 non-expressor |
CYP4F2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2108622 | CC | plus | 2 | lower warfarin dosing |
DBH
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1611115 | CC | plus | normal | |
| rs2007153 | AG | minus | 1.5 | normal risk of schizophrenia in limited study |
DGKH
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1012053 | AC | plus | 2 | 0.625x reduced risk of Bipolar Disorder. |
| rs4142110 | CC | plus | normal |
DIO1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs11206244 | CC | plus | 1 | no increased risk of thyroid hormone metabolism problems |
DNM1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3003609 | CT | plus | ? |
DPP6
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10260404 | CC | plus | 2 | 1.60x risk of developing ALS |
DRD2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs6277 | TT | minus | 2 | normal schizophrenia risk, learns NoGo faster |
DRD4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs11246226 | AA | plus | 1 | increased risk of schizophrenia in limited study |
DSP
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2076295 | GT | plus | 1.2 | One copy of the risk allele (G), slightly increased risk for pulmonary fibrosis |
EGF
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4444903 | AG | plus | 2 | 3.5x risk of hep-cancer in cirrhosis patients; higher glioma risk |
EGFR
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs763317 | AG | plus | increased lung cancer risk for never-smoking females | |
| rs2293347 | GG | minus | 1.1 | among NSCLC patients, better Gefitinib response; common |
ELAC2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs5030739 | AG | minus | 1.3 | Slight increase (1.3x) in risk for prostate cancer |
ERAP1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10050860 | CC | plus | 1.3 | Normal risk (about 0.1%) for Ankylosing Spondylitis. |
| rs30187 | CC | plus | 1.2 | Normal low risk (0.1%) for ankylosing spondylitis. |
ERCC2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs13181 | TT | plus | 1 | Normal risk for cutaneous melanoma |
ESR1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2881766 | TT | plus | 1.5 | Slightly increased risk for pregnancy-induced hypertension |
| rs9340799 | AA | plus | 2 | Women have lower risk of Endometriosis but normal risk for Endometrial Cancer, and more cognitive impairment with age. |
| rs3020314 | CC | plus | 0.42x reduced lymphoma risk | |
| rs2179922 | AG | plus |
F12
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1801020 | CT | minus | 1.5 | 1.31x increased risk of heart disease |
FAAH
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs324420 | AC | plus | normal |
FABP2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1799883 | GG | minus | This genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates. |
FADS1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs174548 | CG | plus | intermediate phosphatidylcholine values |
FADS2
FAM71F1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs6971091 | AA | plus | >2x increased risk for familial obesity |
FCGR2A
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1801274 | CT | minus | 1.5 | complex; generally greater risk for cancer progression |
FGFR2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3750817 | CT | plus | 2 | 0.78x reduced risk for breast cancer |
| rs2981579 | CT | minus | 1.20x risk for breast cancer | |
| rs2981578 | AG | minus | 1.20x increased breast cancer risk | |
| rs1219648 | AG | plus | 2 | 1.20x risk for breast cancer |
| rs2420946 | CT | plus | 2 | 1.20x risk for breast cancer |
| rs2981582 | CT | minus | 3 | 1.3x higher risk of ER+ breast cancer |
FGFR4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs351855 | CT | minus | 2 | 1.2x increased risk for prostate cancer |
FKBP5
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs7757037 | AG | plus | 0.68x decreased risk for bipolar disorder | |
| rs1360780 | CT | plus | 2 | 1.3x increased risk for depression |
FTO
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1558902 | TT | plus | Normal | |
| rs3751812 | GG | plus | normal | |
| rs9939609 | TT | plus | 1.5 | lower risk of obesity and Type-2 diabetes |
| rs16953002 | GG | plus | 1 | Slightly lower risk of melanoma in individuals with low BMI |
FUT1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs838133 | CT | minus | 1.2 | Sweeth tooth tendency; slightly higher odds of preferring candy |
FUT2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs492602 | CT | minus | 1 | Normal B12 levels |
GABRA2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs279858 | AG | minus | None |
GADL1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs17026688 | CC | plus | 1 | common |
GATA3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4143094 | TT | plus | 3.1 | higher (by 39%) risk for colorectal cancer correlated with consumption of processed meats |
GBA
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs104886460 | TT | minus | 7 | Gaucher disease |
GCK
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1799884 | AG | minus | 2 | 1.3x increased risk for Type 2 Diabetes. Mothers have babies 27g heavier. |
GDF5
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs143383 | CT | minus | 1.2 | 1.1x increased risk for osteoarthritis |
GLCCI1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs37973 | AA | plus | 2 | possibly better response to inhaled corticosteroids in asthma |
GNB3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs5443 | CC | plus | 1.5 | normal, but higher risk for several conditions |
GPX4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs713041 | TT | plus | >1.3x increased risk of death if diagnosed with breast cancer |
GRIK4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1954787 | CC | plus | ~10% more likely to respond to citalopram |
GSK3B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs334558 | GG | plus | common |
GSTP1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1695 | AG | plus | ? |
GYPB
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs7683365 | AG | plus | 1 | MNS blood group S/s status predicted |
HCRTR2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2653349 | GG | plus | 1.1 | 2-6x increased risk for cluster headaches |
HERC2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs12913832 | GG | plus | 2.5 | blue eye color, 99% of the time |
| rs1667394 | AA | minus | 1.5 | blond hair & blue eyes is 4x more likely |
HMGA2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10784502 | CT | plus | 1 | Slightly higher intracranial volume |
| rs1042725 | CT | plus | 1.5 | ~0.4cm taller |
HMGCR
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs17238540 | GT | plus | not as responsive to statin treatment |
HNF1B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4430796 | AA | plus | 2.1 | 1.38x increased risk for prostate cancer |
HSD17B4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs25640 | AG | plus | 1 | benign polymorphism |
HTR2A
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs6313 | CC | minus | higher risk for RA | |
| rs6311 | CC | plus | 3 | 3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants. |
IFNL4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs12979860 | CC | plus | 2 | ~80% of such hepatitis C patients respond to treatment |
IGF2BP2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4402960 | GT | plus | 2 | 1.2x increased risk for type-2 diabetes, ~1x risk for gestational diabetes |
| rs1470579 | AC | plus | 1.2x increased risk for type-2 diabetes |
IKZF1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4132601 | GT | plus | 1.7 | somewhat (1.7x) increased risk for acute lymphoblastic leukemia |
IKZF3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs9303277 | CC | plus | 1 | Normal risk of developing primary biliary cirrhosis |
IL10
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1800871 | CT | minus | 0.5x decreased risk for endometriosis | |
| rs1800896 | AA | minus | 2 | 1.8x increased prostate cancer risk |
IL12B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3212227 | AA | minus | 1.5 | 1.43x increased risk of developing psoriasis and psoriatic arthritis |
| rs3213094 | GG | minus |
IL17A
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2275913 | AA | plus | 3x increased gastric cancer risk. Increased risk of Acute Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation |
IL18
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs187238 | GG | minus | 2.5 | hypertension increases risk 3.75x for sudden cardiac death |
IL1B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs16944 | GG | plus | 2 | Slightly increased (~2x or less) risk for certain mental disorders |
IL23R
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1004819 | CT | minus | 1 | 1.5x risk of Crohn’s disease, 1.2 for developing ankylosing spondylitis |
| rs2201841 | CT | minus | 2 | 1.5x increased risk for Crohn’s disease; 2x increased risk for Graves’ disease |
| rs11209026 | GG | plus | 1.1 | Normal, but higher risk for certain autoimmune diseases. |
| rs10889677 | AC | plus | 2 | 1.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves disease |
| rs1495965 | GG | minus | normal risk |
IL2RA
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs12722489 | GG | minus | a slight increase in risk of developing multiple sclerosis |
IL2RB
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs743777 | AA | plus |
IL4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2243250 | TT | plus | 2 | 0.33x decreased risk for myocardial infarction if younger than 50 |
IL6
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1800795 | CG | plus | complex; see details |
IVD
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2034650 | CT | minus | 0.13x risk of pulmonary fibrosis in Koreans |
KCNQ1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs11601907 | CT | plus | 1 | variant allele is designated benign in ClinVar |
KIF1B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10492972 | CC | plus | conflicting reports; possible slight increased risk for multiple sclerosis |
KITLG
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs995030 | GG | plus | 1.5 | non-protective against testicular cancer |
| rs4474514 | AA | plus | 1.8 | >3x increased testicular cancer risk for men |
LIPC
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1800588 | CC | plus | 1.6 | normal HDL-C levels |
LOC105377329
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs356220 | CC | plus |
LOC729065
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2200733 | CT | plus | 3 | 1.4x increased risk of Atrial Fibrillation and ischemic stroke. |
LOXL1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3825942 | AG | plus | 1.8 | possibly lower glaucoma risk |
| rs2165241 | CT | plus | 2.2 | 4.4x increased risk of exfoliation glaucoma |
LPL
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs326 | GG | plus | normal risk |
LPP
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs9851967 | TT | plus | 0.88x risk of vitiligo in Chinese |
LRP1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs11172113 | CC | plus | 1.2 | 0.8x lower risk for migraines |
LRP5
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4988300 | GT | plus | ||
| rs3736228 | CT | plus | 1.3 | increased risk for osteoporosis |
LTA
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1041981 | CC | plus | normal |
MAP2K5
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs12593813 | AG | plus | 1.5 | 0.71x risk for restless legs |
| rs4489954 | GT | plus | 1.5 | 0.69x risk risk of developing restless legs syndrome |
| rs2241423 | GG | plus | 1 | Normal risk for obesity |
MAPT
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1800547 | AA | plus | 1 | MAPT H1/H1 diplotype |
MC4R
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2229616 | GG | minus | 2 | lower BMI; decreased obesity risk |
MCM6
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4988235 | CC | minus | 2.5 | likely to be lactose intolerant as an adult |
| rs182549 | CC | plus | 2 | possibly lactose intolerant |
MEIS1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs12469063 | AA | plus | 1 | Normal risk of developing restless legs syndrome |
| rs2300478 | TT | plus | 1 | Normal risk of developing restless legs syndrome |
MMEL1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3890745 | AG | minus |
MMP9
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3918242 | TT | plus | 1.33x increased risk for MI; also check haplotype |
MTHFD1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2236225 | CT | minus | 1.25 | Possible increased risk of birth defects |
MTHFS
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs6495446 | TT | plus | 2 | 0.64x reduced risk for chronic kidney disease |
MTNR1B
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10830963 | GG | plus | 3.1 | increased type-2 diabetes risk; higher gestational diabetes risk |
MTRR
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1801394 | GG | plus | 2 | 1.4x higher risk for meningiomas |
MTTP
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3816873 | CT | plus | None |
NADSYN1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs12785878 | GT | plus | 1.5 | slightly increased (1.2x) risk for vitamin D insufficiency |
NAT1
NAT2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1799930 | AG | plus | 1.7 | Possibly slightly increased risk of hearing loss |
NBPF3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4654748 | CT | plus | 2 | 1.45 ng/mL lower Vitamin B6 blood concentration |
NCAN
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1064395 | GG | plus | Normal risk of bipolar disorder or schizophrenia |
NF1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs137854557 | GG | plus | 1 | Miscall in Ancestry v2c data (most likely) |
NGF
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs6330 | CT | minus | normal |
NOS1AP
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10918594 | CG | plus | average QT interval |
NOS2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4795067 | AG | plus | 1.2 | slight increase in risk for psoriatic arthritis |
NOS3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs891512 | AA | plus | 3 | Higher blood pressure than G;G |
NPPA
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs5065 | AG | plus | normal risk |
NQO1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1800566 | CT | minus | 1.8 | Possible Lower Lung Cancer risk |
NRG1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs6994992 | CT | plus | 1 |
NSD1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs28932178 | CT | plus |
OCA2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4778138 | AA | plus | 1 | freckles more likely |
OPRM1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2281617 | CC | plus | 2 | Normal (better) response to amphetamine |
OXTR
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs53576 | AA | plus | 2.8 | Lack of empathy? |
P2RY11
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2305795 | AG | plus | 2 | 1.28x higher risk of narcolepsy compared to (G;G) genotype |
PADI4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2240340 | AG | minus | 1.5 | slightly increased (1.5x) risk for RA |
PADI6
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs7538876 | AG | plus | 1.8 | Normal risk of Basal Cell Carcinoma. |
PALB2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs420259 | TT | minus | 1.5 | Normal risk of Bipolar Disorder. |
PCSK9
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs11591147 | GT | plus | 3.5 | 2-3 fold lower risk of heart disease |
PDE4B
PDE4D
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs966221 | CC | minus | 1.5 | 1.5x increased stroke risk certain populations |
PKD1L3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs9938025 | AA | plus | 2 | Lower odds of dry earwax in Europeans. |
PLCE1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2274223 | AG | plus | 2 | 1.5x increased risk for stomach & esophageal cancer (seen in Han Chinese) |
PLD3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs145999145 | GG | plus | 1 | common |
PNPLA3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs738409 | GG | minus | 2.1 | most common genotype; slightly less damage from alcohol |
PON1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs662 | AA | minus | 2 | ~2x higher risk of of coronary heart disease reported in some studies, but lower risk seen in other studies |
| rs854560 | AA | plus | 2 | higher risk for heart disease, diabetic retinopathy |
POR
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1057868 | CT | plus | normal |
PPARGC1A
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2290602 | GT | plus | 2 | 2.7x increased risk for nonalcoholic fatty liver disease |
PRNP
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1799990 | AG | plus | 2.1 | Resistance to vCJD (PrP 129 Met/Val heterozygote), 4.6x reduced risk of sporadic CJD and 0.87x reduced risk for late-onset Alzheimer in a Caucasian population |
PRRC2A
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1046089 | AA | plus | normal |
PTGS2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs5275 | CT | minus | 0.68x decreased risk for bladder cancer |
PTPRD
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1975197 | CC | minus | 1 | Normal risk of developing restless legs syndrome |
| rs4626664 | GG | plus | 1 | Normal risk of developing restless legs syndrome |
RELN
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3914132 | TT | plus | 1 | Normal (not lower) otosclerosis risk |
RGS2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4606 | GG | plus | complex; possible association with anxiety related behaviours |
RNASEL
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3738579 | CT | minus | 1.1 | 0.5x decreased risk for cervical cancer, HNSCC, and breast cancer (reported in 2008) |
RTEL1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs6010620 | GG | plus | 1.4 | 1.4x higher risk for glioma development; but this is the common allele. 1.4x higher risk for atopic dermatitis in Han Chinese |
SCARB1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs5888 | CT | minus | 2.5 | 3x higher risk for age-related macular degeneration |
| rs4765623 | CT | plus | more likely to gain weight if taking olanzapine |
SELE
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs5361 | AC | minus | normal risk |
SERPINF1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1136287 | TT | plus | 2 | 3.9x increased risk of wet ARMD in a Taiwanese Chinese population |
SHROOM3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs17319721 | AG | plus | 1.5 | reported to have some negative associations with kidney function |
SLC14A1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1058396 | GG | plus | 1 | Jk(a+/b-) Kidd blood group, barring other variants |
SLC19A1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs12483377 | AG | plus | 1 | benign polymorphism |
SLC2A9
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs6855911 | AA | plus | 2 | normal, but increased risk of gout |
| rs12498742 | AA | plus | 1.5 | 1.25 increased risk for gout |
| rs7442295 | AA | plus | 2 | ~4x higher risk for hyperuracemia |
| rs3775948 | CG | minus | 1.6 | slightly higher risk for gout |
SLC30A8
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs13266634 | CC | plus | 3 | increased risk for type-2 diabetes |
| rs3802177 | CC | minus | 1.16x increased risk for type-2 diabetes |
SLC45A2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs16891982 | CC | plus | 1.1 | generally non-European, but if European, 7x more likely to have black hair |
SLC4A1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2285644 | CC | minus | 1 | Diego blood group Di(a-b+); found in > 99% of Caucasians and Blacks |
| rs5036 | AG | minus | 2 | Memphis variant of erythrocyte Band 3 glycoprotein |
SLC6A2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3785143 | CT | plus | 1 | may be associated with ADHD |
SLC6A3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs27072 | CC | plus | 2 | 2x risk of severe alcohol withdrawal. Possible increased odds of ADHD. |
| rs460000 | CC | minus | 2 | Better response to amphetamine |
SLC6A4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1042173 | GT | minus | normal | |
| rs25532 | CC | minus | may be part of a haplotype associated with OCD |
SLCO1B3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs11045585 | AA | plus | 2 | 24% chance (lower than average) of docetaxel-induced leukopenia/neutropenia |
SMAD7
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4939827 | CC | plus | 1 | 0.73x decreased risk for colorectal cancer |
| rs12953717 | CC | plus | 1.37x increased risk for colorectal cancer | |
| rs4464148 | TT | plus | 1 | Normal risk for colorectal cancer |
SMOC2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs13208776 | GG | plus | higher risk for generalized vitiligo |
SNAP25
SNCA
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs356168 | AA | plus | 2 | slight decrease in risk for Parkinson’s disease |
| rs2736990 | TT | minus | 1 | Normal risk of developing Parkinson’s Disease |
SOD2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4880 | CT | minus | 1.1 | complex! see rs4880 |
SOD3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs699473 | TT | plus | 1 | Normal brain tumor risk |
SPIB
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3745516 | AG | plus | 1.5 | Slightly increased risk of developing primary biliary cirrhosis |
SPINK5
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2303067 | AA | plus | 1.8x risk |
SREBF1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs11868035 | AA | plus | 1.19x increased risk for T2D |
STAT4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10168266 | CC | plus | normal risk of Sjogren’s syndrome | |
| rs7574865 | GG | plus | 1 | normal risk of rheumatoid arthritis, SLE, Sjögren’s syndrome, type-1 diabetes, and primary biliary cirrhosis. |
| rs7582694 | GG | plus | normal |
SULT2A1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2547231 | TT | minus | 2 | Increased blood metabolite levels |
TAS2R38
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs713598 | GG | minus | 1.1 | Possibly unable to taste bitter in some foods. |
TBX21
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4794067 | TT | plus | 1.1 | Lower risk of Aspirin Induced Asthma. Normal (higher) risk of lupus and intractable Grave’s Disease. |
| rs17250932 | TT | plus | 1.1 | Normal. Not protective against lupus and intractable Graves’ disease. |
TCF7L2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3814570 | CC | plus | 1 | Normal risk of developing Crohn’s disease |
| rs7903146 | TT | plus | 3.5 | 2x increased risk for Type-2 diabetes |
| rs12255372 | TT | plus | 2.2 | slight increases (~1.5x) in risk for type-2 diabetes and possibly breast cancer and aggressive prostate cancer |
TERT
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2736100 | GT | minus | 1.3 | 1.3x higher risk for glioma development, 2.1x risk of pulmonary fibrosis |
TF
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1049296 | CT | plus | 1.1 | Heterozygote carrying both C1 and C2 transferrin subtypes; very slightly higher risk for Alzheimers |
TGFB1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1800469 | CC | minus | 1 | lower TGF-β1 levels, higher risk for COPD? |
TLR2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4696480 | AT | plus | 1 | preterm birth |
TLR3
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3775291 | AG | minus | 2.1 | 0.71x decreased risk for dry age related macular degeneration |
TLR4
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1554973 | CT | plus | increased risk for chorionic plate inflammation |
TMPRSS6
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs855791 | CC | minus | normal |
TNFSF15
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4979462 | CC | plus | 1 | Normal risk of developing primary biliary cirrhosis |
TOMM40
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2075650 | AG | plus | 2 | possibly 2x higher Alzheimer’s risk |
TP53
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1042522 | GG | minus | 2 | Common variant. Slightly shorter lifespan. |
TPH2
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs4570625 | GT | plus | normal | |
| rs4565946 | CC | plus | Risk of early-onset OCD | |
| rs1843809 | TT | plus | 1 | Most common genotype worldwide |
TRA
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1154155 | GT | plus | 1.5 | 1.94x increased risk for narcolepsy |
TRAF1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs3761847 | AG | plus | 2.1 | 1.32 x risk of rheumatoid arthritis. |
TRPM8
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs10166942 | CT | plus | 1.1 | 0.85x lower risk for migraines |
TYR
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs1042602 | AA | plus | associated with the absence of freckles |
VDR
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs731236 | CT | minus | ||
| rs1544410 | AG | minus | Intermediate risk of low bone mineral density disorders | |
| rs4516035 | TT | plus | normal |
VEGFA
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs699947 | AA | plus | 1.36x increased risk for thyroid cancer in men |
VKORC1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs8050894 | CG | plus | average warfarin response (~5 mg/day) | |
| rs9923231 | CT | plus | 2 | reduced warfarin dose if treated for VTE |
WWC1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs17070145 | CT | plus | 2 | increased memory performance |
XPC
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs2228001 | AC | minus | normal |
XRCC1
| rs# | Генотип | Ориентация | Значимость | Описание |
|---|---|---|---|---|
| rs25487 | GG | minus | 2 | 2x higher risk for skin cancer; possibly other cancers |